Regulatory Framework
Context of Use Explorer
ConductOrganoid as a complementary New Approach Methodology for OECD Test Guideline 426 developmental neurotoxicity assessment.
Step 1: The Problem
The Scale of the Problem
Prenatal substance exposure affects 1 in 20 US births. Current testing relies on OECD TG 426 animal studies that cost $1–2M per compound, take 6+ months, and use species with fundamentally different brain development.
~120
compounds ever tested under TG 426
Due to cost and time barriers
$1–2M
per compound tested
Prohibitive for most substances
6+ months
per study
From dosing to final report
The gap: Thousands of substances with prenatal exposure potential have never been tested for developmental neurotoxicity. Human-derived New Approach Methodologies (NAMs) can complement animal testing by providing faster, cheaper, and more human-relevant screening.